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KMID : 0438420140210040233
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Korean Journal of Bone Metabolism
2014 Volume.21 No. 4 p.233 ~ p.241
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Regulation of NFATc1 in Osteoclast Differentiation
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Kim Jung-Ha
Kim Nack-Sung
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Abstract
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Osteoclasts are unique cells that degrade the bone matrix. These large multinucleated cells differentiate from the monocyte/macrophage lineage upon stimulation by two essential cytokines, macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor-kappa B (NF-κB) ligand (RANKL). Activation of transcription factors such as microphthalmia transcription factor (MITF), c-Fos, NF-κB, and nuclear factor-activated T cells c1 (NFATc1) is required for sufficient osteoclast differentiation. In particular, NFATc1 plays the role of a master transcription regulator of osteoclast differentiation. To date, several mechanisms, including transcription, methylation, ubiquitination, acetylation, and non-coding RNAs, have been shown to regulate expression and activation of NFATc1. In this review, we have summarized the various mechanisms that control NFATc1 regulation during osteoclast differentiation.
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KEYWORD
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Gene expression regulation, NFATc transcription factors, Osteoclasts, RANK ligand
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